Phkg2 ferroptosis
Webb24 nov. 2024 · PHKG2 encodes a subunit of phosphorylase kinase, and the knockdown of PHKG2 inhibits ferroptosis induced by erastin . In our study, five of these genes …
Phkg2 ferroptosis
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Webb7 juni 2024 · Background: Ferroptosis, a regulated cell death which is driven by the iron-dependent peroxidation of lipids, plays an important role in cancer. However, studies about ferroptosis-related Long non-coding RNAs (lncRNAs) in breast cancer (BC) are limited. Besides, the prognostic role of ferroptosis-related lncRNAs and their relationship to … Webb22 dec. 2024 · Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the …
Webb24 juni 2024 · Ferroptosis, a form of programmed cell death induced by excess iron-dependent lipid peroxidation product accumulation, plays a critical role in cancer. … WebbAlthough some publications investigated the correlations between ferroptosis and LUAD, [10] [11][12][13] this study aimed to explore multi-omics data on LUAD including mRNA expression, protein ...
Webb2 dec. 2024 · GPX4, system X c −, NRF2, p53, and UPS are the main ferroptosis regulators in lung cancer. Ferroptosis has a close relationship with the immune system status in lung cancer. The expression of ferroptosis-related genes including, ALOX15, PEBP1, GLS2, and PHKG2, positively predict prognosis. Webb31 aug. 2024 · A ferroptosis-related gene signature for overall survival prediction and immune infiltration in lung squamous cell carcinoma A ferroptosis-related gene …
Webb28 juni 2024 · Ferroptosis is a new type of iron-dependent programmed cell death. In recent years, its role in the diagnosis and treatment of multiple tumors, including non …
Webbferroptosis inducers inhibit GPX4 by covalently targeting the active site selenocysteine, leading to accumulation of PUFA hydroperox-ides. In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessary for ferroptosis and that the covalent inhibition of the catalytic selenocysteine in Gpx4 candies from the 60\u0027sWebb21 mars 2024 · Ferroptosis is a newly discovered form of regulatory cell death induced by iron-dependent lipid peroxidation. Infection with Helicobacter pylori (H. p… fish pond prismatic shardWebb1 jan. 2024 · Ferroptosis is an iron-dependent non-apoptotic cell death that can elicited by pharmacological inhibiting the cystine/glutamate antiporter, system Xc − (type I) or directly binding and loss of activity of GPx4 (Type II) in cancer cells with high level RAS-RAF-MEK pathway activity or p53 expression, but not in normal cells. fish pond pipe connectorsWebb10 aug. 2024 · The small molecule RSL3 has been identified as an inducer of ferroptosis and its MoA, that involves binding and inhibition of GPX4 , was recently reported (Yang et al. 2014) as determined by affinity-based proteomics. GPX4 could also be inhibited upstream as a result of the inhibition of selenoprotein (SELT), for instance by directly … fishpond proWebbFerroptosis is a novel type of cell death in hepatic IRI that involves small molecules that inhibit glutathione biosynthesis or glutathione peroxidase 4 (GPX4), which is a glutathione‑dependent antioxidant enzyme, causing mitochondrial damage. candies for wedding favorsWebbCompendia expression profiles ?: GTEx compendium Human tissue compendium (Novartis) Global Cancer Map (Broad Institute) NCI-60 cell lines (National Cancer Institute): Advanced query: Further investigate these 64 genes : Gene families ?: Categorize these 64 genes by gene family : Show members (show 65 source identifiers mapped to 64 genes) fish pond pump rock coversWebbför 2 dagar sedan · In this study, we assume that deep learning model learns the nonlinear interaction between molecular environment (expression profile of ferroptosis regulators) and ferroptosis regulation score (potential regulation level of ferroptosis), so as to make accurate prediction. fishpond photo books