The pleiotropic benefits of statins

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Webb1 dec. 2024 · In addition, the synergistic anti-cancer effects of statins, when combined with other (anti-cancer) drugs, will be discussed in this paper. 2. Pleiotropic properties of statins. “Pleiotropy” originates from the Greek words “pleion” (more) and “tropos” (direction/way), meaning “more than one way”. Webb3 mars 2024 · Despite effective lipid reduction and corresponding benefits for cardiovascular disease prevention and treatment, statins have pleiotropic effects potentially increasing the risk of ischemic heart ...

Statins and the Eye: What You Might Not Know - Review of …

Webbwith cardiac history. How might the increasing use of statins, with pleiotropic effects, including antiinflammatory activity, alter the effects of immunization? With universal recommendations for influenza vaccination for persons > 6 months of age, how will herd or community immunity affect population levels of influenza activity? Webb18 maj 2024 · The pleiotropic benefits of statins include the ability to reduce CD47 and amplify the effect of pro-efferocytic therapies in atherosclerosis ... Role of statin pleiotropism in acute coronary syndromes and stroke. Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute coronary syn... first peas to the table

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WebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, … WebbPleiotropic effects · Risk factors Abstract Introduction: Autoimmune thyroiditis seems to be associ-ated with increased cardiometabolic risk. Statins, the main-stay of cardiovascular risk reduction and prevention, were found to reduce thyroid antibody titers. The aim of this study was to investigate plasma markers of cardiometabolic risk in WebbPleiotropic effects of the HMG-CoA reductase inhibitors Christos G Mihos, Orlando SantanaColumbia University Division of Cardiology, Mount Sinai Heart Institute, Miami … first peco meter cpu

Pleiotropic effects of statins: new therapeutic targets in drug …

Pleiotropic Effects of Statins IntechOpen

Webb20 dec. 2024 · As statin use expanded, novel biochemical and clinical benefits were discovered, leading to the development of the pleiotropic model that proposes multiple mechanisms for positive effect, both cholesterol dependent and independent. 2 Branching off cholesterol studies, downstream inhibition of isoprenoid intermediate formation was … WebbPitavastatin has been shown to have similar pleiotropic effects to other statins, including decreasing platelet activation and improving cardiac and endothelial function. 32 Thus, it … first peanut butter brandWebb1 apr. 2002 · These agents appear to reduce bone fractures and may improve insulin sensitivity and reduce the likelihood of persons progressing from impaired glucose … first peasant movement in india

"WebbAccumulating evidence have suggested that statins, in addition to LDL-C lowering, exhibited properties of plaque stabilization and endothelial homeostasis; anti … " - The pleiotropic benefits of statins

The pleiotropic benefits of statins

Beneficial Cardiovascular Pleiotropic Effects of Statins

Webbför 6 timmar sedan · select article The pleiotropic effects of high-density lipoproteins and apolipoprotein A-I. https: ... select article The advantages and pitfalls of genetic analysis in the diagnosis and management of lipid disorders. ... Statins and diabetes: What are the connections? Naveed Sattar. Article 101749 View PDF. WebbDOI: 10.1016/S1734-1140(10)70247-4 Corpus ID: 4742496; Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells. @article{Meda2010EffectsOS, title={Effects of statins on nitric oxide/cGMP signaling in human umbilical vein endothelial cells.}, author={Claudia Meda and Christian Plank and …

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WebbPleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, … WebbAlthough some trials evaluating the effects of statins on kidney disease outcomes have shown benefits of statins, 16,17,33 others have shown no effect. 18,34,35 However, most of these studies ... Dhawan V, Sharma PL, Kumar P. Pleiotropic effects of statins: new therapeutic targets in drug design. Naunyn Schmiedebergs Arch Pharmacol. 2016;389(7 ...

Webb5 jan. 2012 · Pleiotropic effects of statins include improvement of endothelial dysfunction, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory … Webb19 apr. 2010 · This article is part I of a 2-part review, and it focuses on the pleiotropic effects of statins at the cellular level. References. Buhaescu I., Izzedine H. Mevalonate pathway: a review of clinical and therapeutical implications . ... Statins: Risk-Benefits and Role in Treating Dyslipidemias.

Webb13 feb. 2024 · Indeed, several randomized controlled trials showed the benefits of statins both in the primary and secondary prevention of cardiovascular disease, which appear to be primarily due to LDL cholesterol (LDL-C) reduction but also to antiinflammatory, antithrombotic, antioxidant, and plaque-stabilizing effects [5,6,7,8,9,10,11,12]. Webb26 okt. 2024 · Statins are a class of drugs used to lower low-density lipoprotein cholesterol and are amongst the most prescribed medications worldwide. Most statins work as a …

WebbIn RA patients, the risk of CVD is reduced by statin treatment, and statin discontinuation is associated with an increased cardiovascular disease risk. Summary: The combined …

WebbSaeid Ghavami Associate Editor at Elsevier, Frontiers, PLOS, and MDPI publishing group first pediatric allergist appointmentWebb1 okt. 2012 · In recent years, however, a number of additional non-lipid-lowering, or ‘pleiotropic’, effects of statins have been suggested to contribute to their efficacy in … first pearl jam albumWebb20 maj 2024 · One of the factors to be considered when evaluating outcomes of lipid-lowering treatment with statins is their solubility. Therefore, the role of both hydrophilic … first pearl harbor movieWebbMost pleiotropic effects of statins in cell cultures can be reversed by the addition of mevalonate. Effects that are mediated by Rho GTPases are attributed to the isoprenoid, geranylgeranlpyrophosphate (GGPP). Therefore, increasing mevalonate or GGPP concentrations within extra hepatic cells could limit the benefits of statins. first pediatric dental visitWebb15 maj 2024 · Statins also impart a modest benefit in concentrations of triglycerides, high-density lipoproteins (HDL) and very low-density lipoproteins (VLDL). 2 Moreover, statins exert pleiotropic effects such as improvement of endothelial function, enhancing the stability of atherosclerotic plaques, decreasing oxidative stress and inflammation, and … first pearlsWebb1 juni 2004 · These non-lipid-lowering (pleiotropic) effects of statin therapy are believed to include antiinflammatory actions, property to reverse endothelial dysfunction by decreasing LDL oxidation and increasing nitric oxide bioavailability. first pediatric dentistWebbPertaining to the endocrine system the benefits of statins can extend to patients with the polycystic ovarian syndrome and thyroid disease. However, there is also increasing … first peas to the table book